Compound Detail
CHEMBL317768
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL317768 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FXQIHDKTUNWVRH-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
264.3
MW (Da)
2.86
ALogP
3
HBA
0
HBD
43.4
PSA (Ų)
0.62
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.29
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor CHEMBL2095217 | IC50 | 5.29 | 5.29 | 5100.0 | 1 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 5.29 | 5.29 | 5100.0 | 1 |
| Proto-oncogene tyrosine-protein kinase Src CHEMBL267 | IC50 | 4.6 | 4.6 | 25000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 | IC50 | = | 5100.0 | nM | 5.29 | Inhibition of bFGF-mediated tyrosine phosphorylation | 11063616 |
| Fibroblast growth factor receptor | IC50 | = | 5100.0 | nM | 5.29 | Inhibitory activity against fibroblast growth factor receptor (FGFr) | - |
| Proto-oncogene tyrosine-protein kinase Src | IC50 | = | 25000.0 | nM | 4.6 | Inhibitory activity against c-src tyrosine kinase | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11063616 | 10.1021/jm000161d | Fibroblast growth factor receptor 1 | 1 |
| - | 10.1016/S0960-894X(97)10110-X | Fibroblast growth factor receptor | 1 |
| - | 10.1016/S0960-894X(97)10110-X | Platelet-derived growth factor receptor | 1 |
| - | 10.1016/S0960-894X(97)10110-X | Proto-oncogene tyrosine-protein kinase Src | 1 |
Data from ChEMBL 36 via Core Engine