Assay Detail
Binding
CHEMBL676885
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Inhibitory activity against fibroblast growth factor receptor (FGFr)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Fibroblast growth factor receptor (CHEMBL2095217) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
1-Oxo-3-aryl-1H-indene-2-carboxylic acid derivatives as selective inhibitors of fibroblast growth factor receptor-1 tyrosine kinase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.02 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL316508 | — | — | 1 | 5.38 |
| CHEMBL329706 | — | — | 1 | 5.33 |
| CHEMBL317768 | — | — | 1 | 5.29 |
| CHEMBL99724 | — | — | 1 | 5.27 |
| CHEMBL316556 | — | — | 1 | 5.21 |
| CHEMBL323564 | — | — | 1 | 5.19 |
| CHEMBL98447 | — | — | 1 | 5.17 |
| CHEMBL99077 | — | — | 1 | 5.04 |
| CHEMBL85589 | — | — | 1 | 5.00 |
| CHEMBL101457 | — | — | 1 | 4.97 |
| CHEMBL316567 | — | — | 1 | 4.82 |
| CHEMBL99352 | — | — | 1 | 4.68 |
| CHEMBL98396 | — | — | 1 | 4.60 |
| CHEMBL99049 | — | — | 1 | 4.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL316508 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL329706 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL317768 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL99724 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL316556 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL323564 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL98447 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL99077 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL85589 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL101457 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL316567 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL99352 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL98396 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL99049 | — | IC50 | = | 44000.0 | nM | 4.36 |