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Compound Detail

CHEMBL316556

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COC(=O)C1=C(c2ccccc2)c2cc(Cl)ccc2C1=O.COC(=O)C1=C(c2ccccc2)c2ccc(Cl)cc2C1=O

Basic Information

ChEMBL ID CHEMBL316556
Phase Preclinical
Structure Type MOL
InChI Key QSCANXICFWJNLA-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

597.5
MW (Da)

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C34H22Cl2O6
MW 597.45

Activity Summary

IC50 1 meas. best 5.21

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Fibroblast growth factor receptor
CHEMBL2095217
IC50 5.21 5.21 6200.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Fibroblast growth factor receptor IC50 = 6200.0 nM 5.21 Inhibitory activity against fibroblast growth factor receptor (FGFr) -

Literature References

PubMed DOI Target Context # Activities
- 10.1016/S0960-894X(97)10110-X Fibroblast growth factor receptor 1
- 10.1016/S0960-894X(97)10110-X Platelet-derived growth factor receptor 1
- 10.1016/S0960-894X(97)10110-X Proto-oncogene tyrosine-protein kinase Src 1

Data from ChEMBL 36 via Core Engine