Assay Detail
Functional
CHEMBL678589
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Inhibition of bFGF-mediated tyrosine phosphorylation
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
3-(3,5-Dimethoxyphenyl)-1,6-naphthyridine-2,7-diamines and related 2-urea derivatives are potent and selective inhibitors of the FGF receptor-1 tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.11 | 5.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL304414 | — | — | 1 | 5.35 |
| CHEMBL317768 | — | — | 1 | 5.29 |
| CHEMBL89363 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL304414 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL317768 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL89363 | — | IC50 | = | 20000.0 | nM | 4.70 |