Assay Detail
Binding
CHEMBL881401
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Inhibitory concentration against c-Jun N-terminal kinase 3
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of 6-anilinoindazoles as selective inhibitors of c-Jun N-terminal kinase-3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.95 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL194806 | — | — | 1 | 8.85 |
| CHEMBL399167 | — | — | 1 | 8.72 |
| CHEMBL199136 | — | — | 1 | 8.48 |
| CHEMBL198687 | — | — | 1 | 8.47 |
| CHEMBL197613 | — | — | 1 | 8.28 |
| CHEMBL198821 | — | — | 1 | 7.68 |
| CHEMBL440566 | — | — | 1 | 7.52 |
| CHEMBL197698 | — | — | 1 | 7.50 |
| CHEMBL383177 | — | — | 1 | 7.32 |
| CHEMBL254443 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL194806 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL399167 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL199136 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL198687 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL197613 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL198821 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL440566 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL197698 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL383177 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL254443 | — | IC50 | = | 202.0 | nM | 6.70 |