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Assay Detail

CHEMBL881499

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration against (MMP-1) matrix metalloprotease-1
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Interstitial collagenase (CHEMBL332)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Receptor flexibility in de novo ligand design and docking.
Alberts IL, Todorov NP, Dean PM.
J Med Chem (2005) 48 : 6585 -6596
PubMed 16220975 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 7.48 8.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL414852 1 8.89
CHEMBL370842 1 8.89
CHEMBL198634 1 8.89
CHEMBL198227 1 8.52
CHEMBL371101 1 8.00
CHEMBL197931 1 8.00
CHEMBL199149 1 8.00
CHEMBL199120 1 8.00
CHEMBL198543 1 7.66
CHEMBL198778 1 7.66
CHEMBL196460 1 7.66
CHEMBL198055 1 7.66
CHEMBL383801 1 6.92
CHEMBL371643 1 6.92
CHEMBL197729 1 6.92
CHEMBL194243 1 6.92
CHEMBL197842 1 6.04
CHEMBL371715 1 6.04
CHEMBL381631 1 6.04
CHEMBL197632 1 6.04

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL414852 IC50 = 1.3 nM 8.89
CHEMBL370842 IC50 = 1.3 nM 8.89
CHEMBL198634 IC50 = 1.3 nM 8.89
CHEMBL198227 IC50 = 3.0 nM 8.52
CHEMBL371101 IC50 = 10.0 nM 8.00
CHEMBL197931 IC50 = 10.0 nM 8.00
CHEMBL199149 IC50 = 10.0 nM 8.00
CHEMBL199120 IC50 = 10.0 nM 8.00
CHEMBL198543 IC50 = 22.0 nM 7.66
CHEMBL198778 IC50 = 22.0 nM 7.66
CHEMBL196460 IC50 = 22.0 nM 7.66
CHEMBL198055 IC50 = 22.0 nM 7.66
CHEMBL383801 IC50 = 121.0 nM 6.92
CHEMBL371643 IC50 = 121.0 nM 6.92
CHEMBL197729 IC50 = 121.0 nM 6.92
CHEMBL194243 IC50 = 121.0 nM 6.92
CHEMBL197842 IC50 = 920.0 nM 6.04
CHEMBL371715 IC50 = 920.0 nM 6.04
CHEMBL381631 IC50 = 920.0 nM 6.04
CHEMBL197632 IC50 = 920.0 nM 6.04