Assay Detail
Binding
CHEMBL881507
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against protein-tyrosine phosphatase 1B by PNPP enzyme assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based design and discovery of protein tyrosine phosphatase inhibitors incorporating novel isothiazolidinone heterocyclic phosphotyrosine mimetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.70 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL382311 | — | — | 1 | 6.72 |
| CHEMBL196526 | — | — | 1 | 5.76 |
| CHEMBL193691 | — | — | 1 | 5.52 |
| CHEMBL373105 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL382311 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL196526 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL193691 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL373105 | — | IC50 | = | 16000.0 | nM | 4.80 |