Assay Detail
Binding
CHEMBL881772
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Inhibitory activity against cathepsin L from human
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.41 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL372979 | — | — | 1 | 7.47 |
| CHEMBL195454 | — | — | 1 | 7.33 |
| CHEMBL195505 | — | — | 1 | 7.17 |
| CHEMBL182956 | — | — | 1 | 6.45 |
| CHEMBL371133 | — | — | 1 | 5.64 |
| CHEMBL184514 | — | — | 1 | 5.43 |
| CHEMBL426819 | — | — | 1 | 5.41 |
| CHEMBL194914 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL372979 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL195454 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL195505 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL182956 | — | IC50 | = | 352.0 | nM | 6.45 |
| CHEMBL371133 | — | IC50 | = | 2274.0 | nM | 5.64 |
| CHEMBL184514 | — | IC50 | = | 3725.0 | nM | 5.43 |
| CHEMBL426819 | — | IC50 | = | 3903.0 | nM | 5.41 |
| CHEMBL194914 | — | IC50 | > | 10000.0 | nM | - |