Assay Detail
Binding
CHEMBL881773
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Inhibitory activity against cathepsin S from human
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.40 | 6.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182956 | — | — | 1 | 6.99 |
| CHEMBL372979 | — | — | 1 | 6.92 |
| CHEMBL195454 | — | — | 1 | 6.35 |
| CHEMBL195505 | — | — | 1 | 6.04 |
| CHEMBL184514 | — | — | 1 | 5.70 |
| CHEMBL426819 | — | — | 1 | - |
| CHEMBL194914 | — | — | 1 | - |
| CHEMBL371133 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182956 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL372979 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL195454 | — | IC50 | = | 451.0 | nM | 6.35 |
| CHEMBL195505 | — | IC50 | = | 902.0 | nM | 6.04 |
| CHEMBL184514 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL426819 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL194914 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL371133 | — | IC50 | > | 10000.0 | nM | - |