Assay Detail
Functional
CHEMBL882107
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of ADP (1.25 x 10E-6 M)-induced platelet aggregation in rat PRP (wistar)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of a new chemically and metabolically stable prostacyclin analogue with high and long-lasting oral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.34 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1139 | EPOPROSTENOL | 4.0 | 1 | 8.59 |
| CHEMBL323744 | — | — | 1 | 8.49 |
| CHEMBL494 | ILOPROST | 4.0 | 1 | 7.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1139 | EPOPROSTENOL | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL323744 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL494 | ILOPROST | IC50 | = | 11.4 | nM | 7.94 |