Assay Detail
Binding
CHEMBL882167
Review assay metadata, readout intent, target linkage, and publication context from the same page.
50% Inhibition against Norepinephrine transporter in rat cerebral cortex by displacing [3H]nisoxetine radioligand
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and transporter binding properties of 3beta-[4'-(phenylalkyl, -phenylalkenyl, and -phenylalkynyl)phenyl]tropane-2beta-carboxylic acid methyl esters: evidence of a remote phenyl binding domain on the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.16 | 7.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2310877 | — | — | 1 | 7.97 |
| CHEMBL2310867 | — | — | 1 | 7.68 |
| CHEMBL2310871 | — | — | 1 | 7.56 |
| CHEMBL2373962 | — | — | 1 | 7.22 |
| CHEMBL2310874 | — | — | 1 | 7.15 |
| CHEMBL2310868 | — | — | 1 | 7.11 |
| CHEMBL3350431 | — | — | 1 | 7.08 |
| CHEMBL2310872 | — | — | 1 | 6.46 |
| CHEMBL84680 | — | — | 1 | 6.43 |
| CHEMBL2310869 | — | — | 1 | 6.09 |
| CHEMBL1790051 | — | — | 1 | 6.04 |
| CHEMBL2310881 | — | — | 1 | 5.90 |
| CHEMBL2310876 | — | — | 1 | 5.83 |
| CHEMBL2310873 | — | — | 1 | 5.83 |
| CHEMBL2310884 | — | — | 1 | 5.80 |
| CHEMBL2310883 | — | — | 1 | 5.71 |
| CHEMBL2310865 | — | — | 1 | 5.64 |
| CHEMBL50157 | — | — | 1 | 5.41 |
| CHEMBL2310866 | — | — | 1 | 5.41 |
| CHEMBL2310875 | — | — | 1 | 5.35 |
| CHEMBL2310880 | — | — | 1 | 5.18 |
| CHEMBL2310879 | — | — | 1 | 5.15 |
| CHEMBL2310870 | — | — | 1 | 5.02 |
| CHEMBL2310878 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2310877 | — | IC50 | = | 10.8 | nM | 7.97 |
| CHEMBL2310867 | — | IC50 | = | 21.1 | nM | 7.68 |
| CHEMBL2310871 | — | IC50 | = | 27.4 | nM | 7.56 |
| CHEMBL2373962 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2310874 | — | IC50 | = | 70.2 | nM | 7.15 |
| CHEMBL2310868 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL3350431 | — | IC50 | = | 83.2 | nM | 7.08 |
| CHEMBL2310872 | — | IC50 | = | 347.0 | nM | 6.46 |
| CHEMBL84680 | — | IC50 | = | 372.0 | nM | 6.43 |
| CHEMBL2310869 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL1790051 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL2310881 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL2310876 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL2310873 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL2310884 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL2310883 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL2310865 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL50157 | — | IC50 | = | 3910.0 | nM | 5.41 |
| CHEMBL2310866 | — | IC50 | = | 3921.0 | nM | 5.41 |
| CHEMBL2310875 | — | IC50 | = | 4450.0 | nM | 5.35 |
| CHEMBL2310880 | — | IC50 | = | 6670.0 | nM | 5.18 |
| CHEMBL2310879 | — | IC50 | = | 7060.0 | nM | 5.15 |
| CHEMBL2310870 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL2310878 | — | IC50 | = | 14200.0 | nM | 4.85 |