Assay Detail

CHEMBL882173

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Binding

Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig

ChEMBL ↗

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Target

Substance-P receptor (CHEMBL3942) ↗

Open DB target context

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Substance-P receptor (CHEMBL3942) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Substance-P receptor

CHEMBL3942

Anchored from Assay target.

Protein identity Substance-P receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Cavia porcellus
Tissue	Striatum
Subcellular	Membrane
Confidence	9 — Direct single protein target
Curated By	Intermediate

Target

Substance-P receptor (CHEMBL3942) ↗

Type	SINGLE PROTEIN
Organism	Cavia porcellus

Publication

Synthesis, in vitro binding profile, and autoradiographic analysis of [3H]-cis-3-[(2-methoxybenzyl)amino]-2-phenylpiperidine, a highly potent and selective nonpeptide substance P receptor antagonist radioligand.

Rosen T, Seeger TF, McLean S, Desai MC, Guarino KJ, Bryce D, Pratt K, Heym J, Chalabi PM, Windels JH.
J Med Chem (1993) 36 : 3197 -3201
PubMed 7693945 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	2	9.67	9.77

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL441225	CP-99994	—	2	9.77

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL441225	CP-99994	Ki	=	0.17	nM	9.77
CHEMBL441225	CP-99994	Ki	=	0.27	nM	9.57