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Assay Detail

CHEMBL882435

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro anti-HIV activity assessed by measuring [3H]-thymidine uptake in human peripheral blood mononuclear (PBM) cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558)
Type ADMET

Publication

Synthesis and in vitro anti-human immunodeficiency virus activity of artemisinin (qinghaosu)-related trioxanes
Jung M, Schinazi RF
Bioorg Med Chem Lett (1994) 4 : 931 -934
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 7 5.20 5.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2368117 1 5.89
CHEMBL301267 ARTEMOTIL 2.0 1 4.51
CHEMBL171407 1 -
CHEMBL2367467 DEOXOARTEMISININ 1 -
CHEMBL269671 ARTEMISININ 3.0 1 -
CHEMBL129 ZIDOVUDINE 4.0 1 -
CHEMBL2368325 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2368117 IC50 = 1300.0 nM 5.89
CHEMBL301267 ARTEMOTIL IC50 = 30900.0 nM 4.51
CHEMBL171407 IC50 > 100000.0 nM -
CHEMBL2367467 DEOXOARTEMISININ IC50 > 100000.0 nM -
CHEMBL269671 ARTEMISININ IC50 > 100000.0 nM -
CHEMBL129 ZIDOVUDINE IC50 > 100000.0 nM -
CHEMBL2368325 IC50 > 100000.0 nM -