Assay Detail
Binding
CHEMBL882441
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In vitro inhibition of cyclic AMP phosphodiesterase from human platelets.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Inhibitors of cyclic AMP phosphodiesterase. 1. Analogues of cilostamide and anagrelide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.76 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69139 | LIXAZINONE | 2.0 | 1 | 8.00 |
| CHEMBL760 | ANAGRELIDE | 4.0 | 1 | 7.10 |
| CHEMBL34431 | CILOSTAMIDE | 2.0 | 1 | 6.77 |
| CHEMBL420838 | — | — | 1 | 6.72 |
| CHEMBL67513 | — | — | 1 | 6.54 |
| CHEMBL102920 | — | — | 1 | 5.94 |
| CHEMBL105666 | — | — | 1 | 5.94 |
| CHEMBL103495 | — | — | 1 | 5.89 |
| CHEMBL102273 | — | — | 1 | 5.87 |
| CHEMBL65882 | — | — | 1 | 5.82 |
| CHEMBL316542 | — | — | 1 | 5.75 |
| CHEMBL102657 | — | — | 1 | 5.47 |
| CHEMBL101969 | — | — | 1 | 5.44 |
| CHEMBL102852 | — | — | 1 | 5.36 |
| CHEMBL103863 | — | — | 1 | 5.00 |
| CHEMBL316590 | — | — | 1 | 4.89 |
| CHEMBL103878 | — | — | 1 | 4.68 |
| CHEMBL100112 | — | — | 1 | 4.28 |
| CHEMBL103557 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69139 | LIXAZINONE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL760 | ANAGRELIDE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL34431 | CILOSTAMIDE | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL420838 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL67513 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL102920 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL105666 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL103495 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL102273 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL65882 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL316542 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL102657 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL101969 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL102852 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL103863 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL316590 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL103878 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL100112 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL103557 | — | IC50 | = | 100000.0 | nM | 4.00 |