Compound Detail
CHEMBL420838
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Basic Information
| ChEMBL ID | CHEMBL420838 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VYOUBFGYIXHFAA-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
362.5
MW (Da)
4.42
ALogP
4
HBA
1
HBD
58.6
PSA (Ų)
0.76
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphodiesterase 3 CHEMBL2094125 | IC50 | 6.72 | 6.72 | 190.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphodiesterase 3 | IC50 | = | 190.0 | nM | 6.72 | In vitro inhibition of cyclic AMP phosphodiesterase from human platelets. | 3027338 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 3027338 | 10.1021/jm00385a011 | Phosphodiesterase 3 | 1 |
| 3027338 | 10.1021/jm00385a011 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine