Assay Detail
Binding
CHEMBL882450
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Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.50 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL198124 | — | — | 1 | 8.24 |
| CHEMBL197646 | — | — | 1 | 8.08 |
| CHEMBL197664 | — | — | 1 | 7.42 |
| CHEMBL198617 | — | — | 1 | 7.01 |
| CHEMBL371899 | — | — | 1 | 6.94 |
| CHEMBL371753 | — | — | 1 | 6.77 |
| CHEMBL364061 | — | — | 1 | 6.37 |
| CHEMBL194202 | — | — | 1 | 6.13 |
| CHEMBL194588 | — | — | 1 | 5.91 |
| CHEMBL370221 | — | — | 1 | 5.91 |
| CHEMBL198123 | — | — | 1 | 5.26 |
| CHEMBL445331 | — | — | 1 | 5.25 |
| CHEMBL382750 | — | — | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL198124 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL197646 | — | Ki | = | 8.39 | nM | 8.08 |
| CHEMBL197664 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL198617 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL371899 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL371753 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL364061 | — | Ki | = | 423.0 | nM | 6.37 |
| CHEMBL194202 | — | Ki | = | 745.0 | nM | 6.13 |
| CHEMBL194588 | — | Ki | = | 1242.0 | nM | 5.91 |
| CHEMBL370221 | — | Ki | = | 1242.0 | nM | 5.91 |
| CHEMBL198123 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL445331 | — | Ki | = | 5566.0 | nM | 5.25 |
| CHEMBL382750 | — | Ki | = | 6300.0 | nM | 5.20 |