Assay Detail
Binding
CHEMBL882455
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity towards rat Nicotinic acetylcholine receptor alpha2-beta2 using 0.5 nM [3H]epibatidine
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha2/beta2 (CHEMBL1907592) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Epibatidine analogues as selective ligands for the alpha(x)beta2-containing subtypes of nicotinic acetylcholine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 9.82 | 10.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | — | 1 | 10.60 |
| CHEMBL197830 | — | — | 1 | 10.46 |
| CHEMBL291961 | — | — | 1 | 10.43 |
| CHEMBL372133 | — | — | 1 | 10.40 |
| CHEMBL197526 | — | — | 1 | 10.36 |
| CHEMBL198228 | — | — | 1 | 10.28 |
| CHEMBL185612 | — | — | 1 | 10.19 |
| CHEMBL372638 | — | — | 1 | 10.18 |
| CHEMBL185060 | — | — | 1 | 10.10 |
| CHEMBL372326 | — | — | 1 | 9.61 |
| CHEMBL58935 | — | — | 1 | 9.19 |
| CHEMBL382533 | — | — | 1 | 8.96 |
| CHEMBL197725 | — | — | 1 | 8.81 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | Ki | = | 0.025 | nM | 10.60 |
| CHEMBL197830 | — | Ki | = | 0.035 | nM | 10.46 |
| CHEMBL291961 | — | Ki | = | 0.037 | nM | 10.43 |
| CHEMBL372133 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL197526 | — | Ki | = | 0.044 | nM | 10.36 |
| CHEMBL198228 | — | Ki | = | 0.053 | nM | 10.28 |
| CHEMBL185612 | — | Ki | = | 0.064 | nM | 10.19 |
| CHEMBL372638 | — | Ki | = | 0.066 | nM | 10.18 |
| CHEMBL185060 | — | Ki | = | 0.079 | nM | 10.10 |
| CHEMBL372326 | — | Ki | = | 0.245 | nM | 9.61 |
| CHEMBL58935 | — | Ki | = | 0.643 | nM | 9.19 |
| CHEMBL382533 | — | Ki | = | 1.11 | nM | 8.96 |
| CHEMBL197725 | — | Ki | = | 1.54 | nM | 8.81 |
| CHEMBL3 | NICOTINE | Ki | = | 12.0 | nM | 7.92 |