Assay Detail
Binding
CHEMBL882479
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for Adenosine A2 receptor in corpora striata of rats using [3H]NECA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.28 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL477 | ADENOSINE | 4.0 | 1 | 8.30 |
| CHEMBL139000 | (R)-PIA | — | 1 | 4.52 |
| CHEMBL262083 | N6-PHENYLADENOSINE | — | 1 | 4.30 |
| CHEMBL420705 | (S)-PIA | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL477 | ADENOSINE | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL139000 | (R)-PIA | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL262083 | N6-PHENYLADENOSINE | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL420705 | (S)-PIA | Ki | = | 100000.0 | nM | 4.00 |