Assay Detail
Binding
CHEMBL882591
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Inhibitory concentration against cloned human thyroid hormone receptor beta 1
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A new class of high affinity thyromimetics containing a phenyl-naphthylene core.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.27 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1544 | LIOTHYRONINE | 4.0 | 1 | 9.59 |
| CHEMBL198367 | — | — | 1 | 9.52 |
| CHEMBL194242 | — | — | 1 | 9.52 |
| CHEMBL196642 | — | — | 1 | 9.52 |
| CHEMBL41036 | — | — | 1 | 8.96 |
| CHEMBL193864 | — | — | 1 | 8.74 |
| CHEMBL198875 | — | — | 1 | 8.74 |
| CHEMBL193615 | — | — | 1 | 8.14 |
| CHEMBL371245 | — | — | 1 | 8.05 |
| CHEMBL195079 | — | — | 1 | 7.89 |
| CHEMBL372428 | — | — | 1 | 7.66 |
| CHEMBL196613 | — | — | 1 | 7.54 |
| CHEMBL195327 | — | — | 1 | 6.26 |
| CHEMBL193851 | — | — | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1544 | LIOTHYRONINE | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL198367 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL194242 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL196642 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL41036 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL193864 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL198875 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL193615 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL371245 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL195079 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL372428 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL196613 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL195327 | — | IC50 | = | 545.0 | nM | 6.26 |
| CHEMBL193851 | — | IC50 | = | 2140.0 | nM | 5.67 |