Compound Detail
CHEMBL193851
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Basic Information
| ChEMBL ID | CHEMBL193851 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RYDWJBNYCSGOFO-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
313.1
MW (Da)
4.12
ALogP
3
HBA
2
HBD
66.8
PSA (Ų)
0.89
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.67
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Thyroid hormone receptor beta CHEMBL1947 | IC50 | 5.67 | 5.67 | 2140.0 | 1 |
| Thyroid hormone receptor alpha CHEMBL1860 | IC50 | 5.44 | 5.44 | 3605.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Thyroid hormone receptor beta | IC50 | = | 2140.0 | nM | 5.67 | Inhibitory concentration against cloned human thyroid hormone receptor beta 1 | 16099653 |
| Thyroid hormone receptor alpha | IC50 | = | 3605.0 | nM | 5.44 | Inhibitory concentration against cloned human thyroid hormone receptor alpha 1 | 16099653 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16099653 | 10.1016/j.bmcl.2005.06.093 | Thyroid hormone receptor alpha | 1 |
| 16099653 | 10.1016/j.bmcl.2005.06.093 | Thyroid hormone receptor beta | 1 |
| 16099653 | 10.1016/j.bmcl.2005.06.093 | Thyroid hormone receptor | 1 |
Data from ChEMBL 36 via Core Engine