Assay Detail
Binding
CHEMBL882600
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against cKit with 4 uM Biotin-Ahx-AEEEYFFLFA-amide for 1 hr at ambient temperature
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Mast/stem cell growth factor receptor Kit (CHEMBL1936) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Thienopyrimidine ureas as novel and potent multitargeted receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 7.11 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL196363 | — | — | 1 | 8.22 |
| CHEMBL371329 | — | — | 1 | 8.05 |
| CHEMBL365784 | — | — | 1 | 7.82 |
| CHEMBL371206 | — | — | 1 | 7.72 |
| CHEMBL371889 | — | — | 1 | 7.72 |
| CHEMBL382517 | — | — | 1 | 7.66 |
| CHEMBL198297 | — | — | 1 | 7.58 |
| CHEMBL425749 | — | — | 1 | 7.57 |
| CHEMBL196747 | — | — | 1 | 7.57 |
| CHEMBL370545 | — | — | 1 | 7.55 |
| CHEMBL366241 | — | — | 1 | 7.55 |
| CHEMBL372174 | — | — | 1 | 7.54 |
| CHEMBL197592 | — | — | 1 | 7.50 |
| CHEMBL196499 | — | — | 1 | 7.48 |
| CHEMBL197353 | — | — | 1 | 7.43 |
| CHEMBL371510 | — | — | 1 | 7.42 |
| CHEMBL195828 | — | — | 1 | 7.37 |
| CHEMBL194236 | — | — | 1 | 7.32 |
| CHEMBL445394 | — | — | 1 | 7.30 |
| CHEMBL195955 | — | — | 1 | 7.30 |
| CHEMBL196615 | — | — | 1 | 7.27 |
| CHEMBL438797 | — | — | 1 | 7.17 |
| CHEMBL371225 | — | — | 1 | 7.09 |
| CHEMBL198267 | — | — | 1 | 7.08 |
| CHEMBL194321 | — | — | 1 | 6.96 |
| CHEMBL370325 | — | — | 1 | 6.85 |
| CHEMBL197635 | — | — | 1 | 6.80 |
| CHEMBL381034 | — | — | 1 | 6.76 |
| CHEMBL194366 | — | — | 1 | 6.75 |
| CHEMBL381207 | — | — | 1 | 6.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL196363 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL371329 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL365784 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL371206 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL371889 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL382517 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL198297 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL425749 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL196747 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL366241 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL370545 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL372174 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL197592 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL196499 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL197353 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL371510 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL195828 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL194236 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL195955 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL445394 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL196615 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL438797 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL371225 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL198267 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL194321 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL370325 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL197635 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL381034 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL194366 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL381207 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL371332 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL198155 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL198601 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL194842 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL372388 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL371379 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL196636 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL382112 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL369908 | — | IC50 | = | 960.0 | nM | 6.02 |