Assay Detail
Binding
CHEMBL882607
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Inhibitory concentration against TIE2 using biotinylated poly(Glu-Tyr) (10 ng/well) for 1 hr at ambient temperature
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Thienopyrimidine ureas as novel and potent multitargeted receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 6.44 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL381207 | — | — | 1 | 7.77 |
| CHEMBL370325 | — | — | 1 | 7.00 |
| CHEMBL371329 | — | — | 1 | 6.96 |
| CHEMBL198297 | — | — | 1 | 6.96 |
| CHEMBL197635 | — | — | 1 | 6.92 |
| CHEMBL195955 | — | — | 1 | 6.89 |
| CHEMBL382112 | — | — | 1 | 6.85 |
| CHEMBL371206 | — | — | 1 | 6.77 |
| CHEMBL196636 | — | — | 1 | 6.72 |
| CHEMBL382517 | — | — | 1 | 6.68 |
| CHEMBL198155 | — | — | 1 | 6.66 |
| CHEMBL371379 | — | — | 1 | 6.60 |
| CHEMBL197353 | — | — | 1 | 6.58 |
| CHEMBL369908 | — | — | 1 | 6.57 |
| CHEMBL371225 | — | — | 1 | 6.54 |
| CHEMBL366241 | — | — | 1 | 6.47 |
| CHEMBL371889 | — | — | 1 | 6.44 |
| CHEMBL381034 | — | — | 1 | 6.44 |
| CHEMBL196747 | — | — | 1 | 6.40 |
| CHEMBL194842 | — | — | 1 | 6.37 |
| CHEMBL198601 | — | — | 1 | 6.33 |
| CHEMBL195828 | — | — | 1 | 6.29 |
| CHEMBL371890 | — | — | 1 | 6.24 |
| CHEMBL372388 | — | — | 1 | 6.20 |
| CHEMBL196499 | — | — | 1 | 6.07 |
| CHEMBL372755 | — | — | 1 | 6.06 |
| CHEMBL198267 | — | — | 1 | 6.05 |
| CHEMBL194321 | — | — | 1 | 6.05 |
| CHEMBL445394 | — | — | 1 | 6.04 |
| CHEMBL194270 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL381207 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL370325 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL371329 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL198297 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL197635 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL195955 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL382112 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL371206 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL196636 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL382517 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL198155 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL371379 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL197353 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL369908 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL371225 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL366241 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL381034 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL371889 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL196747 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL194842 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL198601 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL195828 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL371890 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL372388 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL196499 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL372755 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL198267 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL194321 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL445394 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL194270 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL194236 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL372174 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL197592 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL438797 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL365784 | — | IC50 | = | 1600.0 | nM | 5.80 |