Assay Detail
Functional
CHEMBL882715
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Cell growth inhibition against human squamous cell carcinoma (SCC25) line
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Methotrexate analogues. 25. Chemical and biological studies on the gamma-tert-butyl esters of methotrexate and aminopterin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.33 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376180 | AMINOPTERIN | 2.0 | 1 | 8.80 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376180 | AMINOPTERIN | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 14.0 | nM | 7.85 |