Assay Detail
Binding
CHEMBL882929
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Inhibitory activity against 5-lipoxygenase enzyme from RBL-1 cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | RBL-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
2,4,5- triarylimidazole inhibitors of IL-1 biosynthesis
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.17 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279767 | — | — | 1 | 6.10 |
| CHEMBL280239 | — | — | 1 | 5.62 |
| CHEMBL17370 | — | — | 1 | 5.57 |
| CHEMBL17158 | — | — | 1 | 5.51 |
| CHEMBL17148 | — | — | 1 | 5.42 |
| CHEMBL279568 | — | — | 1 | 5.39 |
| CHEMBL277724 | — | — | 1 | 5.33 |
| CHEMBL17722 | — | — | 1 | 5.28 |
| CHEMBL17325 | — | — | 1 | 5.25 |
| CHEMBL16925 | — | — | 1 | 5.21 |
| CHEMBL17339 | — | — | 1 | 5.14 |
| CHEMBL16911 | — | — | 1 | 5.14 |
| CHEMBL276063 | — | — | 1 | 5.12 |
| CHEMBL17331 | PD-169316 | — | 1 | 5.10 |
| CHEMBL280265 | — | — | 1 | 4.64 |
| CHEMBL280317 | — | — | 1 | 4.62 |
| CHEMBL17570 | — | — | 1 | 4.31 |
| CHEMBL10 | SB-203580 | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279767 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL280239 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL17370 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL17158 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL17148 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL279568 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL277724 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL17722 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL17325 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL16925 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL17339 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL16911 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL276063 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL17331 | PD-169316 | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL280265 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL280317 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL17570 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL10 | SB-203580 | IC50 | = | 58000.0 | nM | 4.24 |