Assay Detail
Binding
CHEMBL882940
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against rat dihydroorotate dehydrogenase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial (CHEMBL2383) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
SAR, species specificity, and cellular activity of cyclopentene dicarboxylic acid amides as DHODH inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.85 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL973 | TERIFLUNOMIDE | 4.0 | 1 | 8.05 |
| CHEMBL154623 | — | — | 1 | 7.11 |
| CHEMBL157105 | — | — | 1 | 6.30 |
| CHEMBL193371 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL973 | TERIFLUNOMIDE | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL154623 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL157105 | — | IC50 | = | 504.0 | nM | 6.30 |
| CHEMBL193371 | — | IC50 | = | 1200.0 | nM | 5.92 |