Assay Detail
Functional
CHEMBL883263
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Inhibitory activity against HIV-1 IIIB in CEM-SS infected cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
A new class of anti-HIV agents: synthesis and activity of conjugates of HIV protease inhibitors with a reverse transcriptase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 7.89 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL167617 | — | — | 1 | 9.62 |
| CHEMBL353976 | — | — | 1 | 8.42 |
| CHEMBL435451 | — | — | 1 | 8.14 |
| CHEMBL428616 | — | — | 1 | 8.05 |
| CHEMBL167564 | — | — | 1 | 7.72 |
| CHEMBL355661 | — | — | 1 | 7.57 |
| CHEMBL353076 | — | — | 1 | 7.57 |
| CHEMBL414640 | — | — | 1 | 7.40 |
| CHEMBL167568 | — | — | 1 | 7.38 |
| CHEMBL353672 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL167617 | — | EC50 | = | 0.24 | nM | 9.62 |
| CHEMBL353976 | — | EC50 | = | 3.8 | nM | 8.42 |
| CHEMBL435451 | — | EC50 | = | 7.3 | nM | 8.14 |
| CHEMBL428616 | — | EC50 | = | 8.9 | nM | 8.05 |
| CHEMBL167564 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL355661 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL353076 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL414640 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL167568 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL353672 | — | EC50 | = | 90.0 | nM | 7.05 |