Assay Detail
Binding
CHEMBL883277
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Inhibition of Angiotensin I converting enzyme (ACE) in Bothrops jararaca venom
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bothrops jararaca |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2002 Alfred Burger Award Address in Medicinal Chemistry. Natural products and design: interrelated approaches in drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.00 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL347755 | — | — | 1 | 9.22 |
| CHEMBL577 | ENALAPRILAT ANHYDROUS | 4.0 | 1 | 8.92 |
| CHEMBL1237 | LISINOPRIL ANHYDROUS | 4.0 | 1 | 8.92 |
| CHEMBL162360 | — | — | 1 | 7.64 |
| CHEMBL327401 | — | — | 1 | 7.22 |
| CHEMBL152758 | — | — | 1 | 7.05 |
| CHEMBL578 | ENALAPRIL | 4.0 | 1 | 5.92 |
| CHEMBL358439 | — | — | 1 | 5.62 |
| CHEMBL78780 | — | — | 1 | 5.31 |
| CHEMBL277919 | — | — | 1 | 4.16 |
| CHEMBL152188 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL347755 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL577 | ENALAPRILAT ANHYDROUS | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1237 | LISINOPRIL ANHYDROUS | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL162360 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL327401 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL152758 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL578 | ENALAPRIL | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL358439 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL78780 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL277919 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL152188 | — | IC50 | = | 260000.0 | nM | - |