Assay Detail
Functional
CHEMBL883278
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Inhibition of EGF-induced c-fos mRNA expression in BALB/c 3T3 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
4-(Phenylamino)pyrrolopyrimidines: potent and selective, ATP site directed inhibitors of the EGF-receptor protein tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.35 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL306315 | — | — | 1 | 7.00 |
| CHEMBL75177 | — | — | 1 | 6.52 |
| CHEMBL72393 | — | — | 1 | 6.30 |
| CHEMBL74722 | — | — | 1 | 6.22 |
| CHEMBL306081 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL306315 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL75177 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL72393 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL74722 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL306081 | — | IC50 | = | 2000.0 | nM | 5.70 |