Assay Detail
Functional
CHEMBL883290
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of collagen-induced platelet aggregation in human platelet-rich plasma.
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
6,6-Disubstituted Hex-5-enoic acid derivatives as combined thromboxane A2 receptor antagonists and synthetase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 51 | 5.05 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL338420 | — | — | 1 | 6.25 |
| CHEMBL129734 | — | — | 1 | 6.16 |
| CHEMBL277689 | SAMIXOGREL | 2.0 | 1 | 6.00 |
| CHEMBL339812 | — | — | 1 | 5.96 |
| CHEMBL339335 | — | — | 1 | 5.92 |
| CHEMBL339269 | — | — | 1 | 5.92 |
| CHEMBL127017 | — | — | 1 | 5.82 |
| CHEMBL127380 | — | — | 1 | 5.77 |
| CHEMBL338360 | — | — | 1 | 5.55 |
| CHEMBL341094 | — | — | 1 | 5.51 |
| CHEMBL415519 | — | — | 1 | 5.47 |
| CHEMBL126761 | — | — | 1 | 5.47 |
| CHEMBL127683 | — | — | 1 | 5.42 |
| CHEMBL126494 | — | — | 1 | 5.37 |
| CHEMBL340396 | — | — | 1 | 5.30 |
| CHEMBL126577 | — | — | 1 | 5.30 |
| CHEMBL127357 | — | — | 1 | 5.28 |
| CHEMBL65414 | — | — | 1 | 5.24 |
| CHEMBL126196 | — | — | 1 | 5.04 |
| CHEMBL338334 | — | — | 1 | 5.02 |
| CHEMBL126185 | — | — | 1 | 5.02 |
| CHEMBL338241 | — | — | 1 | 5.00 |
| CHEMBL129000 | — | — | 1 | 4.96 |
| CHEMBL126337 | — | — | 1 | 4.96 |
| CHEMBL126373 | — | — | 1 | 4.92 |
| CHEMBL130470 | — | — | 1 | 4.89 |
| CHEMBL129635 | — | — | 1 | 4.80 |
| CHEMBL280728 | RIDOGREL | 2.0 | 1 | 4.80 |
| CHEMBL338419 | — | — | 1 | 4.68 |
| CHEMBL129355 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL338420 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL129734 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL277689 | SAMIXOGREL | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL339812 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL339335 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL339269 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL127017 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL127380 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL338360 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL341094 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL415519 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL126761 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL127683 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL126494 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL126577 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL340396 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL127357 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL65414 | — | EC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL126196 | — | EC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL338334 | — | EC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL126185 | — | EC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL338241 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL129000 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL126337 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL126373 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL130470 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL280728 | RIDOGREL | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL129635 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL338419 | — | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL129355 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL129030 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL127212 | — | EC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL126334 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL338588 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL419774 | — | EC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL340504 | — | EC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL127681 | — | EC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL128022 | — | EC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL125519 | — | EC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL127738 | — | EC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL338546 | — | EC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL126333 | — | EC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL128104 | — | EC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL127682 | — | EC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL339568 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL126654 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL128678 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL128973 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL419790 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL129365 | — | EC50 | > | 100000.0 | nM | - |