Assay Detail
Binding
CHEMBL883545
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]dizocilpine binding to N-methyl-D-aspartate (NMDA) receptor complex in rat brain membranes
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Novel bisbenzamidines and bisbenzimidazolines as noncompetitive NMDA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.99 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269032 | — | — | 1 | 5.92 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 5.59 |
| CHEMBL9185 | — | — | 1 | 5.30 |
| CHEMBL9126 | — | — | 1 | 5.27 |
| CHEMBL9479 | — | — | 1 | 5.20 |
| CHEMBL9516 | — | — | 1 | 5.11 |
| CHEMBL24250 | — | — | 1 | 5.08 |
| CHEMBL25526 | — | — | 1 | 4.93 |
| CHEMBL25403 | — | — | 1 | 4.78 |
| CHEMBL8892 | — | — | 1 | 4.74 |
| CHEMBL276449 | — | — | 1 | 4.45 |
| CHEMBL24029 | — | — | 1 | 4.34 |
| CHEMBL9531 | — | — | 1 | 4.18 |
| CHEMBL9391 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269032 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 2590.0 | nM | 5.59 |
| CHEMBL9185 | — | IC50 | = | 4990.0 | nM | 5.30 |
| CHEMBL9126 | — | IC50 | = | 5320.0 | nM | 5.27 |
| CHEMBL9479 | — | IC50 | = | 6290.0 | nM | 5.20 |
| CHEMBL9516 | — | IC50 | = | 7840.0 | nM | 5.11 |
| CHEMBL24250 | — | IC50 | = | 8350.0 | nM | 5.08 |
| CHEMBL25526 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL25403 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL8892 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL276449 | — | IC50 | = | 35600.0 | nM | 4.45 |
| CHEMBL24029 | — | IC50 | = | 45800.0 | nM | 4.34 |
| CHEMBL9531 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL9391 | — | IC50 | > | 200000.0 | nM | - |