Assay Detail
Binding
CHEMBL883650
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPX
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.89 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL68500 | ALLOXAZINE | — | 1 | 8.42 |
| CHEMBL198942 | — | — | 1 | 7.75 |
| CHEMBL197682 | — | — | 1 | 6.85 |
| CHEMBL196258 | — | — | 1 | 6.82 |
| CHEMBL197669 | ST1535 | 1.0 | 1 | 6.45 |
| CHEMBL198200 | — | — | 1 | 6.29 |
| CHEMBL196259 | — | — | 1 | 5.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL68500 | ALLOXAZINE | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL198942 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL197682 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL196258 | — | Ki | = | 153.0 | nM | 6.82 |
| CHEMBL197669 | ST1535 | Ki | = | 352.3 | nM | 6.45 |
| CHEMBL198200 | — | Ki | = | 518.0 | nM | 6.29 |
| CHEMBL196259 | — | Ki | = | 2330.0 | nM | 5.63 |