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Compound Detail

CHEMBL196259

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Cn1c(-n2nccn2)nc2c(N)nc(CCc3ccccc3)nc21

Basic Information

ChEMBL ID CHEMBL196259
Phase Preclinical
Structure Type MOL
InChI Key ABAHFXBQXJPKNX-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

320.4
MW (Da)
1.31
ALogP
8
HBA
1
HBD
100.3
PSA (Ų)
0.61
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H16N8
MW 320.36
Aromatic Rings 4
Heavy Atoms 24
NP-Likeness -1.06

Activity Summary

Ki 3 meas. best 8.33

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A2a
CHEMBL251
Ki 8.33 8.33 4.7 1
Adenosine receptor A1
CHEMBL226
Ki 7.1 7.1 80.0 1
Adenosine receptor A2b
CHEMBL255
Ki 5.63 5.63 2330.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
16250647 10.1021/jm058018d Adenosine receptor A2a 1
16250647 10.1021/jm058018d Adenosine receptor A2b 1
16250647 10.1021/jm058018d Adenosine receptor A1 1
16250647 10.1021/jm058018d Adenosine receptors; A1 & A2a 1
16250647 10.1021/jm058018d Adenosine receptors; A2a & A2b 1

Data from ChEMBL 36 via Core Engine