Assay Detail
Binding
CHEMBL883687
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Binding affinity against Muscarinic acetylcholine receptor M1 by displacement of [3H]pirenzepine in bovine striatum
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Striatum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Affinity and selectivity of the optical isomers of 3-quinuclidinyl benzilate and related muscarinic antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.80 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL558910 | — | — | 1 | 9.72 |
| CHEMBL549577 | — | — | 1 | 9.70 |
| CHEMBL517712 | ATROPINE | 4.0 | 1 | 9.70 |
| CHEMBL2115342 | — | — | 1 | 9.54 |
| CHEMBL1788199 | — | — | 1 | 9.24 |
| CHEMBL9967 | PIRENZEPINE | 2.0 | 1 | 8.44 |
| CHEMBL1788286 | — | — | 1 | 8.29 |
| CHEMBL2114396 | — | — | 1 | 7.72 |
| CHEMBL2114395 | — | — | 1 | 6.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL558910 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL549577 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL517712 | ATROPINE | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL2115342 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL1788199 | — | Ki | = | 0.57 | nM | 9.24 |
| CHEMBL9967 | PIRENZEPINE | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL1788286 | — | Ki | = | 5.16 | nM | 8.29 |
| CHEMBL2114396 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL2114395 | — | Ki | = | 156.0 | nM | 6.81 |