Assay Detail
Binding
CHEMBL883796
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for inhibitory activity against 5-lipoxygenase in microsome of RBL-1 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | RBL-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel dual inhibitors of 5-lipoxygenase and thromboxane A2 synthetase: synthesis and structure-activity relationships of 3-pyridylmethyl-substituted 2-amino-6-hydroxybenzothiazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.48 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318809 | — | — | 1 | 6.68 |
| CHEMBL105139 | — | — | 1 | 6.64 |
| CHEMBL105386 | — | — | 1 | 6.57 |
| CHEMBL3217077 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318809 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL105139 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL105386 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3217077 | — | IC50 | = | 910.0 | nM | 6.04 |