Assay Detail
Functional
CHEMBL884002
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGF-induced Tyrosine phosphorylation in A431 cells expressing EGF-R
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
S(+)-4-(1-Phenylethylamino)quinazolines as inhibitors of human immunoglobulin E synthesis: potency is dictated by stereochemistry and atomic point charges at N-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.65 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL103864 | — | — | 1 | 7.30 |
| CHEMBL102651 | — | — | 1 | 6.38 |
| CHEMBL103014 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL103864 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL102651 | — | IC50 | = | 419.0 | nM | 6.38 |
| CHEMBL103014 | — | IC50 | = | 538.0 | nM | 6.27 |