Assay Detail
Binding
CHEMBL884033
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for inhibitory concentration against AT1 receptor binding affinity in rat liver
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Nonpeptide angiotensin II receptor antagonists. 2. Design, synthesis, and structure-activity relationships of 2-alkyl-4-(1H-pyrrol-1-yl)-1H-imidazole derivatives: profile of 2-propyl-1-[[2'-(1H-tetrazol-5-yl)-[1,1' -biphenyl]-4-yl]-methyl]-4-[2-(trifluoroacetyl)-1H-pyrrol-1-yl]-1H- imidazole-5-carboxylic acid (CI-996).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.52 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL907 | CARBOXYLIC ACID METABOLITE | — | 1 | 8.80 |
| CHEMBL443269 | — | — | 1 | 8.47 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL907 | CARBOXYLIC ACID METABOLITE | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL443269 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL191 | LOSARTAN | IC50 | = | 5.0 | nM | 8.30 |