Assay Detail
Functional
CHEMBL884067
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Effective molar concentration required to inhibit the replication of HIV-1 in human peripheral blood mononuclear cells by 50% (PBMC) was determined
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Aromatic amino acid phosphoramidate di- and triesters of 3-azido-3-deoxythymidine (AZT) are non-toxic inhibitors of HIV-1 replication
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.88 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2021382 | — | — | 1 | 8.00 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.10 |
| CHEMBL52140 | — | — | 1 | 7.05 |
| CHEMBL53431 | — | — | 1 | 6.52 |
| CHEMBL300454 | — | — | 1 | 6.40 |
| CHEMBL300229 | — | — | 1 | 6.22 |
| CHEMBL432520 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2021382 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL52140 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL53431 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL300454 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL300229 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL432520 | — | EC50 | > | 1000.0 | nM | - |