Assay Detail
Functional
CHEMBL884086
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Inhibitory activity on acetylcholine-induced vasorelaxation of phenylephrine-precontracted rat aorta with intact endothelium
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
6-arylamino-5,8-quinolinediones and 7-arylamino-5,8-isoquinolinediones as inhibitors of endothelium-dependent vasorelaxation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 6.39 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55934 | NAPHTHOQUINONE | — | 1 | 6.90 |
| CHEMBL81257 | — | — | 1 | 6.75 |
| CHEMBL79405 | — | — | 1 | 6.72 |
| CHEMBL315798 | — | — | 1 | 6.67 |
| CHEMBL432368 | — | — | 1 | 6.66 |
| CHEMBL84010 | — | — | 1 | 6.62 |
| CHEMBL83341 | — | — | 1 | 6.60 |
| CHEMBL84360 | — | — | 1 | 6.54 |
| CHEMBL279994 | — | — | 1 | 6.54 |
| CHEMBL79580 | — | — | 1 | 6.52 |
| CHEMBL82885 | — | — | 1 | 6.48 |
| CHEMBL312487 | — | — | 1 | 6.47 |
| CHEMBL84014 | — | — | 1 | 6.44 |
| CHEMBL81679 | — | — | 1 | 6.43 |
| CHEMBL309680 | — | — | 1 | 6.37 |
| CHEMBL83676 | — | — | 1 | 6.36 |
| CHEMBL84282 | — | — | 1 | 6.35 |
| CHEMBL310185 | — | — | 1 | 6.29 |
| CHEMBL79264 | — | — | 1 | 6.27 |
| CHEMBL311126 | — | — | 1 | 6.25 |
| CHEMBL311720 | — | — | 1 | 6.22 |
| CHEMBL83736 | — | — | 1 | 6.22 |
| CHEMBL431395 | — | — | 1 | 6.19 |
| CHEMBL315609 | — | — | 1 | 6.09 |
| CHEMBL312124 | — | — | 1 | 6.03 |
| CHEMBL227744 | NITROARGININE | 1.0 | 1 | 5.96 |
| CHEMBL311957 | — | — | 1 | 5.95 |
| CHEMBL316409 | — | — | 1 | 5.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55934 | NAPHTHOQUINONE | EC50 | = | 127.0 | nM | 6.90 |
| CHEMBL81257 | — | EC50 | = | 178.0 | nM | 6.75 |
| CHEMBL79405 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL315798 | — | EC50 | = | 214.0 | nM | 6.67 |
| CHEMBL432368 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL84010 | — | EC50 | = | 239.0 | nM | 6.62 |
| CHEMBL83341 | — | EC50 | = | 251.0 | nM | 6.60 |
| CHEMBL84360 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL279994 | — | EC50 | = | 288.0 | nM | 6.54 |
| CHEMBL79580 | — | EC50 | = | 302.0 | nM | 6.52 |
| CHEMBL82885 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL312487 | — | EC50 | = | 335.0 | nM | 6.47 |
| CHEMBL84014 | — | EC50 | = | 362.0 | nM | 6.44 |
| CHEMBL81679 | — | EC50 | = | 374.0 | nM | 6.43 |
| CHEMBL309680 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL83676 | — | EC50 | = | 439.0 | nM | 6.36 |
| CHEMBL84282 | — | EC50 | = | 449.0 | nM | 6.35 |
| CHEMBL310185 | — | EC50 | = | 519.0 | nM | 6.29 |
| CHEMBL79264 | — | EC50 | = | 541.0 | nM | 6.27 |
| CHEMBL311126 | — | EC50 | = | 562.0 | nM | 6.25 |
| CHEMBL311720 | — | EC50 | = | 607.0 | nM | 6.22 |
| CHEMBL83736 | — | EC50 | = | 603.0 | nM | 6.22 |
| CHEMBL431395 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL315609 | — | EC50 | = | 805.0 | nM | 6.09 |
| CHEMBL312124 | — | EC50 | = | 937.0 | nM | 6.03 |
| CHEMBL227744 | NITROARGININE | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL311957 | — | EC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL316409 | — | EC50 | = | 1230.0 | nM | 5.91 |