Assay Detail
Functional
CHEMBL884087
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration required for relaxation of rat aorta rings
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.86 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL442023 | — | — | 1 | 6.82 |
| CHEMBL181 | DIAZOXIDE | 4.0 | 1 | 4.89 |
| CHEMBL445330 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL442023 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL181 | DIAZOXIDE | EC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL445330 | — | EC50 | = | 262000.0 | nM | - |