Assay Detail
Functional
CHEMBL884088
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Electropharmacology measured as agonist effects in the rat cortical wedge model
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Selective antagonists at group I metabotropic glutamate receptors: synthesis and molecular pharmacology of 4-aryl-3-isoxazolol amino acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 4.64 | 4.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL176855 | — | — | 1 | 4.64 |
| CHEMBL9698 | — | — | 1 | - |
| CHEMBL368556 | — | — | 1 | - |
| CHEMBL368858 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL176855 | — | EC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL9698 | — | EC50 | = | 590000.0 | nM | - |
| CHEMBL368556 | — | EC50 | = | 990000.0 | nM | - |
| CHEMBL368858 | — | EC50 | > | 1000000.0 | nM | - |