Assay Detail
Functional
CHEMBL884135
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Inhibitory activity against human CCRF-CEM leukemic cell lines.
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-based design of substituted diphenyl sulfones and sulfoxides as lipophilic inhibitors of thymidylate synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.63 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159213 | — | — | 1 | 6.22 |
| CHEMBL161025 | — | — | 1 | 5.85 |
| CHEMBL162076 | — | — | 1 | 5.82 |
| CHEMBL417222 | — | — | 1 | 5.80 |
| CHEMBL158542 | — | — | 1 | 5.70 |
| CHEMBL159144 | — | — | 1 | 5.70 |
| CHEMBL160215 | — | — | 1 | 5.64 |
| CHEMBL159364 | — | — | 1 | 5.57 |
| CHEMBL161450 | — | — | 1 | 5.52 |
| CHEMBL157702 | — | — | 1 | 5.52 |
| CHEMBL291548 | — | — | 1 | 5.46 |
| CHEMBL159209 | — | — | 1 | 5.46 |
| CHEMBL162754 | — | — | 1 | 5.35 |
| CHEMBL161685 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159213 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL161025 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL162076 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL417222 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL158542 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL159144 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL160215 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL159364 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL161450 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL157702 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL291548 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL159209 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL162754 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL161685 | — | IC50 | = | 5800.0 | nM | 5.24 |