Assay Detail
Functional
CHEMBL884194
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against human cytomegalovirus (Davis strain) grown on human foreskin fibroblast cells determined by reduction in plaque formation upon incubation at 37 degrees C with the compound dissolved in DMSO
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
4-Oxo-4,7-dihydrothieno[2,3-b]pyridines as non-nucleoside inhibitors of human cytomegalovirus and related herpesvirus polymerases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.85 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL195453 | — | — | 1 | 6.22 |
| CHEMBL440033 | — | — | 1 | 6.10 |
| CHEMBL194433 | — | — | 1 | 6.05 |
| CHEMBL195916 | — | — | 1 | 6.05 |
| CHEMBL363625 | — | — | 1 | 6.00 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 5.89 |
| CHEMBL197562 | — | — | 1 | 5.89 |
| CHEMBL196949 | — | — | 1 | 5.85 |
| CHEMBL196541 | — | — | 1 | 5.77 |
| CHEMBL195908 | — | — | 1 | 5.75 |
| CHEMBL196632 | — | — | 1 | 5.64 |
| CHEMBL195865 | — | — | 1 | 5.64 |
| CHEMBL372547 | — | — | 1 | 5.57 |
| CHEMBL425740 | — | — | 1 | 5.42 |
| CHEMBL197465 | — | — | 1 | - |
| CHEMBL195452 | — | — | 1 | - |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL195453 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL440033 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL194433 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL195916 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL363625 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL182 | GANCICLOVIR | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL197562 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL196949 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL196541 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL195908 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL196632 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL195865 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL372547 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL425740 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL197465 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL195452 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL184 | ACYCLOVIR | IC50 | > | 20000.0 | nM | - |