Assay Detail
Functional
CHEMBL884244
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration against human GluR6 expressed in HEK293 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Glutamate receptor ionotropic, kainate 2 (CHEMBL3683) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4-Alkyl- and 4-cinnamylglutamic acid analogues are potent GluR5 kainate receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.02 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275040 | KAINIC ACID | 2.0 | 1 | 6.16 |
| CHEMBL59284 | — | — | 1 | 5.89 |
| CHEMBL62057 | — | — | 1 | 5.08 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 4.60 |
| CHEMBL294139 | — | — | 1 | 4.23 |
| CHEMBL58590 | — | — | 1 | 4.15 |
| CHEMBL301536 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275040 | KAINIC ACID | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL59284 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL62057 | — | EC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL294139 | — | EC50 | = | 58300.0 | nM | 4.23 |
| CHEMBL58590 | — | EC50 | = | 70800.0 | nM | 4.15 |
| CHEMBL301536 | — | EC50 | > | 100000.0 | nM | - |