Assay Detail
Binding
CHEMBL884268
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Inhibition of [3H]apomorphine binding to calf caudate membrane preparation (p4)
18
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Aporphines, 36. Dopamine receptor interactions of trihydroxyaporphines. Synthesis, radioreceptor binding, and striatal adenylate cyclase stimulation of 2,10,11-trihydroxyaporphines in comparison with other hydroxylated aporphines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.37 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 9.00 |
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | — | 2 | 8.60 |
| CHEMBL19130 | — | — | 1 | 8.00 |
| CHEMBL35556 | — | — | 1 | 7.62 |
| CHEMBL285414 | — | — | 1 | 7.60 |
| CHEMBL288096 | — | — | 1 | 7.60 |
| CHEMBL286787 | — | — | 1 | 7.60 |
| CHEMBL284248 | — | — | 1 | 7.52 |
| CHEMBL27559 | — | — | 1 | 7.44 |
| CHEMBL36061 | — | — | 1 | 6.95 |
| CHEMBL32330 | — | — | 1 | 6.84 |
| CHEMBL286929 | — | — | 1 | 6.69 |
| CHEMBL283871 | — | — | 1 | 6.41 |
| CHEMBL440846 | — | — | 1 | 6.16 |
| CHEMBL154709 | APOCIDEINE | — | 1 | 5.62 |
| CHEMBL284368 | — | — | 1 | - |
| CHEMBL32392 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL19130 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL35556 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL285414 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL288096 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL286787 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL284248 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL27559 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL36061 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL32330 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL286929 | — | IC50 | = | 204.0 | nM | 6.69 |
| CHEMBL283871 | — | IC50 | = | 394.0 | nM | 6.41 |
| CHEMBL440846 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL154709 | APOCIDEINE | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL284368 | — | IC50 | >= | 5000.0 | nM | - |
| CHEMBL32392 | — | IC50 | > | 10000.0 | nM | - |