Assay Detail
Functional
CHEMBL884272
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Concentration to stimulate the cAMP production in BHK cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BHK |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.44 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL364005 | — | — | 1 | 9.00 |
| CHEMBL193351 | — | — | 1 | 8.54 |
| CHEMBL194305 | — | — | 1 | 8.24 |
| CHEMBL194248 | — | — | 1 | 8.10 |
| CHEMBL365751 | — | — | 1 | 7.80 |
| CHEMBL18785 | RU-24969 | — | 1 | 6.70 |
| CHEMBL267615 | — | — | 1 | 6.15 |
| CHEMBL363417 | — | — | 1 | 5.00 |
| CHEMBL194908 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL364005 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL193351 | — | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL194305 | — | EC50 | = | 5.8 | nM | 8.24 |
| CHEMBL194248 | — | EC50 | = | 7.9 | nM | 8.10 |
| CHEMBL365751 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL18785 | RU-24969 | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL267615 | — | EC50 | = | 710.0 | nM | 6.15 |
| CHEMBL363417 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL194908 | — | EC50 | = | - | nM | - |