Assay Detail
Binding
CHEMBL884337
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards Cholecystokinin type B receptor in mouse cortex membrane
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL2854) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
The design and synthesis of the high efficacy, non-peptide CCK1 receptor agonist PD170292.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.14 | 10.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2062146 | — | — | 1 | 10.08 |
| CHEMBL1121 | SINCALIDE | 4.0 | 1 | 9.52 |
| CHEMBL14153 | PD-170292 | — | 1 | 8.17 |
| CHEMBL62205 | — | — | 1 | 7.50 |
| CHEMBL278780 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2062146 | — | IC50 | = | 0.083 | nM | 10.08 |
| CHEMBL1121 | SINCALIDE | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL14153 | PD-170292 | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL62205 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL278780 | — | IC50 | = | 3600.0 | nM | 5.44 |