Assay Detail
Binding
CHEMBL884365
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Tested for inhibitory activity against dihydrofolate reductase in Lactobacillus casei
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Lacticaseibacillus casei |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
2,4-Diaminothieno[2,3-d]pyrimidine analogues of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.34 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL320811 | — | — | 1 | 5.89 |
| CHEMBL104555 | — | — | 1 | 5.82 |
| CHEMBL107167 | — | — | 1 | 5.70 |
| CHEMBL104770 | — | — | 1 | 4.92 |
| CHEMBL108006 | — | — | 1 | 4.35 |
| CHEMBL321826 | — | — | 1 | - |
| CHEMBL107079 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL320811 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL104555 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL107167 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL104770 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL108006 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL321826 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL107079 | — | IC50 | > | 50000.0 | nM | - |