Assay Detail
Binding
CHEMBL884447
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Modified ibogaine fragments: synthesis and preliminary pharmacological characterization of 3-ethyl-5-phenyl-1,2,3,4,5, 6-hexahydroazepino[4,5-b]benzothiophenes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.67 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | — | 1 | 8.37 |
| CHEMBL343569 | — | — | 1 | 6.31 |
| CHEMBL141863 | — | — | 1 | 5.52 |
| CHEMBL139081 | — | — | 1 | 5.30 |
| CHEMBL341805 | — | — | 1 | 5.30 |
| CHEMBL23529 | — | — | 1 | 4.70 |
| CHEMBL336437 | — | — | 1 | 4.16 |
| CHEMBL222287 | IBOGAINE | 2.0 | 1 | - |
| CHEMBL343956 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL343569 | — | IC50 | = | 491.0 | nM | 6.31 |
| CHEMBL141863 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL139081 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL341805 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL23529 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL336437 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL222287 | IBOGAINE | IC50 | > | 10000.0 | nM | - |
| CHEMBL343956 | — | IC50 | > | 10000.0 | nM | - |