Assay Detail
Binding
CHEMBL884454
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Inhibition of [3H]dopamine uptake at dopamine transporter.
10
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogues at the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.99 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2079586 | — | — | 1 | 7.10 |
| CHEMBL2373962 | — | — | 1 | 6.96 |
| CHEMBL159325 | — | — | 1 | 6.75 |
| CHEMBL1790051 | — | — | 3 | 6.02 |
| CHEMBL172482 | — | — | 1 | 5.60 |
| CHEMBL425862 | — | — | 1 | 5.60 |
| CHEMBL426954 | — | — | 1 | 5.56 |
| CHEMBL120901 | — | — | 1 | 4.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2079586 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2373962 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL159325 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL1790051 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL1790051 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL172482 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL425862 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL426954 | — | IC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL120901 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL1790051 | — | IC50 | = | 200000.0 | nM | - |