Assay Detail
Binding
CHEMBL884520
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Inhibition of rat adrenal 11-beta-hydroxylase
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Cytochrome P450 11B1, mitochondrial (CHEMBL4970) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Selective thromboxane synthetase inhibitors. 1. 1-[(Aryloxy)alkyl]-1H-imidazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.35 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284356 | — | — | 1 | 5.70 |
| CHEMBL30395 | — | — | 1 | 5.00 |
| CHEMBL34041 | — | — | 1 | - |
| CHEMBL423117 | — | — | 1 | - |
| CHEMBL33407 | — | — | 1 | - |
| CHEMBL267473 | DAZOXIBEN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284356 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL30395 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL34041 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL423117 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL33407 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL267473 | DAZOXIBEN | IC50 | > | 100000.0 | nM | - |